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Article

Mutations in the Caenorhabditis elegans U2AF large subunit UAF-1 alter the choice of a 3' splice site in vivo.

PLoS genetics - 1 Nov 2009

Ma Long, Horvitz H Robert

Abstract excerpt

The removal of introns from eukaryotic RNA transcripts requires the activities of five multi-component ribonucleoprotein complexes and numerous associated proteins. The lack of mutations affecting splicing factors essential for animal survival has limited the study of the in vivo regulation of splicing. From a screen for suppressors of the Caenorhabditis elegans unc-93(e1500) rubberband Unc phenotype, we...

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Identifiers

PMID: 19893607
DOI: 10.1371/journal.pgen.1000708
PMCID: PMC2762039

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