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Article

The allele-specific suppressor sup-39 alters use of cryptic splice sites in Caenorhabditis elegans.

Genetics - 1 Mar 2000

Roller A B, Hoffman D C, Zahler A M

Abstract excerpt

Mutations in the Caenorhabditis elegans sup-39 gene cause allele-specific suppression of the uncoordination defect of unc-73(e936). e936 is a point mutation that changes the canonical G at the 5' end of intron 16 to a U. This mutation activates three splice donors, two of which define introns beginning with the canonical GU. Use of these two cryptic splice sites causes loss of reading frame; interestingly these...

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Identifiers

PMID: 10757761
DOI: 10.1093/genetics/154.3.1169
PMCID: PMC1460989

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