Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system

Abstract excerpt

Levodopa, the major treatment for patients with Parkinson's disease, has been shown to induce a variety of compensatory effects, including facilitation of sprouting by dopaminergic neurons, in experimental animals with lesions leading to denervation of the striatum. To better understand the cellular and molecular environment where most of these compensatory changes take place, in particular elements that might...

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