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Article

Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines.

Journal of neurochemistry - 1 May 2003

Baptista Melisa J, O'Farrell Casey, Daya Sneha, Ahmad Rili, Miller David W, Hardy John, Farrer Matthew J, Cookson Mark R

Abstract excerpt

Abnormal accumulation of alpha-synuclein in Lewy bodies is a neuropathological hallmark of both sporadic and familial Parkinson's disease (PD). Although mutations in alpha-synuclein have been identified in autosomal dominant PD, the mechanism by which dopaminergic cell death occurs remains unknown. We investigated transcriptional changes in neuroblastoma cell lines transfected with either normal or mutant (A30P...

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Identifiers

PMID: 12716427
DOI: 10.1046/j.1471-4159.2003.01742.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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