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Article

A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation

15 Jul 1998

Abstract excerpt

Dopamine acting in the striatum is necessary for normal movement and motivation. Drugs that change striatal dopamine neurotransmission can have long-term effects on striatal physiology and behavior; these effects are thought to involve alterations in gene expression. Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose...

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PMID: 9651213
DOI: 10.1523/jneurosci.18-14-05301.1998

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