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Article

Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004

Pethe Kevin, Swenson Dana L, Alonso Sylvie, Anderson Jennifer, Wang Carren, Russell David G

Abstract excerpt

Mycobacterium tuberculosis resides within the phagocytes of its host. It ensures its continued survival through arresting the normal maturation of its phagosome, which is retained within the early endosomal system of the macrophage. Although individual bacterial components have been shown to modulate phagosome biogenesis, the mechanism(s) active in live, intact bacteria remain elusive. We have developed a genetic...

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Identifiers

PMID: 15340136
DOI: 10.1073/pnas.0401657101
PMCID: PMC518761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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