Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the HIV-1 LTR as a promoter of negative sense transcription.

Archives of virology - 1 Dec 2004

Bentley K, Deacon N, Sonza S, Zeichner S, Churchill M

Abstract excerpt

The HIV-1 gene promoter is a bi-directional promoter of transcription. We report the characterization of the negative sense promoter (NSP) by analysis of the effect on negative sense transcription of a series of LTR U3 region substitution mutants. Mutations in the region nt -58 to -183 (positive sense transcription initiation nt +1) reduced transcription to <15% of wild type NSP activity. This region, essential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Gene Expression Regulation, Viral
Share to Gene Products, tat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Long Terminal Repeat

Share to Jurkat Cells

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Up-Regulation

Source

Identifiers

PMID: 15338321
DOI: 10.1007/s00705-004-0386-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the HIV-1 LTR as a promoter of negative sense transcription.PMID 15338321Read ↗

A fourth Sp1 site in the human immunodeficiency virus type 1 long terminal repeat is essential for negative-sense transcription.Semantic proximity Read ↗

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.Semantic proximity Read ↗

Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).Semantic proximity Read ↗

Regulation of HIV‐1 gene expressionSemantic proximity Read ↗

Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promotersSemantic proximity Read ↗

Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeatSemantic proximity Read ↗

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein.Semantic proximity Read ↗

HIV-1 core promoter lacks a simple initiator element but contains a bipartite activator at the transcription start siteSemantic proximity Read ↗

Mutations generated in human immunodeficiency virus type 1 long terminal repeat during vertical transmission correlate with viral gene expression.Semantic proximity Read ↗

A transcriptional regulatory element is associated with a nuclease-hypersensitive site in the pol gene of human immunodeficiency virus type 1Semantic proximity Read ↗

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Semantic proximity Read ↗

Transcriptional activation by bidirectional RNA polymerase II elongation over a silent promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.