Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy.

Skeletal muscle - 7 Nov 2023

Lambert Matthias R, Gussoni Emanuela

Abstract excerpt

The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an indispensable regulator of muscle contraction in slow muscle fibers. Recent advances suggest that TPM3 isoforms hold more extensive functions during skeletal muscle development and in postnatal muscle. Additionally, mutations in the TPM3 gene have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Muscle Fibers, Skeletal
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Muscular Diseases

Share to Mutation

Share to Neurogenetic and Muscular Disorders Research

Share to Tropomyosin

Source

Open in PubMed Open full text

Identifiers

PMID: 37936227
DOI: 10.1186/s13395-023-00327-x
PMCID: PMC10629095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy.PMID 37936227Read ↗

Tropomyosins in skeletal muscle diseases.Semantic proximity Read ↗

A Novel Variant in TPM3 Causing Muscle Weakness and Concomitant Hypercontractile Phenotype.Semantic proximity Read ↗

Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy.Semantic proximity Read ↗

Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres.Semantic proximity Read ↗

TPM3 deletions cause a hypercontractile congenital muscle stiffness phenotype.Semantic proximity Read ↗

Mechanisms of disturbance of the contractile function of slow skeletal muscles induced by myopathic mutations in the tropomyosin TPM3 gene.Semantic proximity Read ↗

Frequency and phenotype of patients carrying TPM2 and TPM3 gene mutations in a cohort of 94 patients with congenital myopathy.Semantic proximity Read ↗

A novel variant in the tropomyosin 3 gene presenting as an adult-onset distal myopathy - a case report.Semantic proximity Read ↗

Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms.Semantic proximity Read ↗

Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion.Semantic proximity Read ↗

Transcript-Based Diagnosis and Expanded Phenotype of an Intronic Mutation in TPM3 Myopathy.Semantic proximity Read ↗

Congenital myopathies: diseases of the actin cytoskeleton.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.