Article
The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers.
Journal of cell science - 1 Nov 1996
Gautel M, Goulding D, Bullard B, Weber K, Fürst D O
Abstract excerpt
The giant sarcomeric protein titin (also described as connectin) is composed mainly of immunoglobulin (Ig)-like and fibronectin type III (fn3)-like domains arranged consecutively. At both ends of the molecule, these domains are interrupted by sequence insertions. The amino terminus of titin is localized in the Z-disk, a structure of great variability in different muscle types. We have determined the...
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