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Article

Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2012

LaBeau-DiMenna Elisa M, Clark Kathleen A, Bauman Kenneth D, Parker Daniel S, Cripps Richard M, Geisbrecht Erika R

Abstract excerpt

Myofibril stability is required for normal muscle function and maintenance. Mutations that disrupt myofibril stability result in individuals who develop progressive muscle wasting, or muscular dystrophy, and premature mortality. Here we present our investigations of the Drosophila l(2)thin [l(2)tn] mutant. The "thin" phenotype exhibits features of the human muscular disease phenotype in that tn mutant larvae show...

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Source

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Identifiers

PMID: 23071324
DOI: 10.1073/pnas.1208408109
PMCID: PMC3497806

Genes

TRIM32

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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