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Article

Ryanodine receptor channelopathies.

Pflugers Archiv : European journal of physiology - 1 Jul 2010

Betzenhauser Matthew J, Marks Andrew R

Abstract excerpt

Ryanodine receptors (RyR) are intracellular Ca2+-permeable channels that provide the sarcoplasmic reticulum Ca2+ release required for skeletal and cardiac muscle contractions. RyR1 underlies skeletal muscle contraction, and RyR2 fulfills this role in cardiac muscle. Over the past 20 years, numerous mutations in both RyR isoforms have been identified and linked to skeletal and cardiac diseases. Malignant...

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Share to Calcium
Share to Channelopathies
Share to Malignant Hyperthermia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Contraction

Share to Myopathy, Central Core

Share to Ryanodine Receptor Calcium Release Channel

Share to Sarcoplasmic Reticulum

Share to Tachycardia, Ventricular

Source

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Identifiers

PMID: 20179962
DOI: 10.1007/s00424-010-0794-4
PMCID: PMC2885589

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