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Article

Contribution of a conserved phenylalanine residue to the activity of Escherichia coli uracil DNA glycosylase.

DNA repair - 5 Oct 2004

Shaw Ryan W, Feller Joyce A, Bloom Linda B

Abstract excerpt

Uracil DNA glycosylase (UDG) excises uracil from DNA to initiate repair of this lesion. This important DNA repair enzyme is conserved in viruses, bacteria, and eukaryotes. One residue that is conserved among all the members of the UDG family is a phenylalanine that stacks with uracil when it is flipped out of the DNA helix into the enzyme active site. To determine what contribution this conserved Phe residue...

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Identifiers

PMID: 15336623
DOI: 10.1016/j.dnarep.2004.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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