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Article

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

Genes & development - 1 Apr 1993

Debbas M, White E

Abstract excerpt

Transformation of primary rodent cells by the adenovirus E1A and E1B oncogenes is a two-step process, where E1A-dependent induction of proliferation is coupled to E1B-dependent suppression of programmed cell death (apoptosis). The E1B gene encodes two distinct transforming proteins, the 19K and 55K proteins, both of which independently cooperate with E1A. E1B 19K or 55K protein, or the human Bcl-2 protein,...

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Identifiers

PMID: 8384580
DOI: 10.1101/gad.7.4.546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.PMID 8384580Read ↗

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cellsSemantic proximity Read ↗

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisSemantic proximity Read ↗

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E2F1 pathways to apoptosisSemantic proximity Read ↗

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19KSemantic proximity Read ↗

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.Semantic proximity Read ↗

The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis.Semantic proximity Read ↗

Lamin proteolysis facilitates nuclear events during apoptosis.Semantic proximity Read ↗

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteinsSemantic proximity Read ↗

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.Semantic proximity Read ↗

Coexpression of mutant p53 and p193 renders embryonic stem cell-derived cardiomyocytes responsive to the growth-promoting activities of adenoviral E1A.Semantic proximity Read ↗

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein.Semantic proximity Read ↗

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