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Article

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

Genes & development - 1 Apr 1993

Debbas M, White E

Abstract excerpt

Transformation of primary rodent cells by the adenovirus E1A and E1B oncogenes is a two-step process, where E1A-dependent induction of proliferation is coupled to E1B-dependent suppression of programmed cell death (apoptosis). The E1B gene encodes two distinct transforming proteins, the 19K and 5...

Topics

Adenovirus E1A Proteins
Adenovirus E1B Proteins
Animals
Apoptosis
Cell Line
Cell Line, Transformed
Cell Transformation, Neoplastic
Cell Transformation, Viral
Cytomegalovirus
DNA Damage
DNA, Viral
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Mutation

Rats

Transfection

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 8384580
DOI: 10.1101/gad.7.4.546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8384580-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.PMID 8384580Read ↗

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cellsSemantic proximity Read ↗

Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisSemantic proximity Read ↗

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Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19KSemantic proximity Read ↗

E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection.Semantic proximity Read ↗

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