Article
The NH2-terminal domain of the human T-cell leukemia virus type 1 capsid protein is involved in particle formation.
Journal of virology - 1 Jun 2001
Rayne F, Bouamr F, Lalanne J, Mamoun R Z
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1) capsid proteins (CA) display similar structures formed by two independently folded N-terminal (NTD) and C-terminal (CTD) domains. To characterize the functions harbored by the HTLV-1 CA domains in particle formation, 12 sites scattered throughout the protein were mutated. The effects of the mutations on Gag membrane...
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