Article
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Autoimmunity reviews - 1 Feb 2002
Kallenberg Cees G M, Rarok Agnieszka, Stegeman Coen A, Limburg Pieter C
Abstract excerpt
Antineutrophil cytoplasmic autoantibodies (ANCA) directed to proteinase 3 (PR3-ANCA) or myeloperoxidase (MPO-ANCA) are closely associated with the idiopathic systemic necrotizing vasculitides, in particular Wegener's granulomatosis, microscopic polyangiitis and its renal limited manifestation, and Churg Strauss Syndrome. Many in vitro studies show that those ANCA have phlogistic potential, particularly at the...
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