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Article

T-lymphocytes and disease mechanisms in Wegener's granulomatosis.

Kidney & blood pressure research - 1 Jan 2009

Hua Fan, Wilde Benjamin, Dolff Sebastian, Witzke Oliver

Abstract excerpt

The mechanisms underlying Wegener's granulomatosis (WG) are not well understood. The role of T-cells in the pathogenesis of WG has only recently come into focus of research. This review presents recent developments regarding the role of T-cells in WG. The occurrence of anti-neutrophil-cytoplasmic antibodies (ANCA) directed against proteinase-3 (PR-3) is a hallmark of WG. ANCA seem to mediate vasculitic damage in...

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Identifiers

PMID: 19907189
DOI: 10.1159/000256409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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