Article
Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.
The Journal of biological chemistry - 12 Nov 2004
Zhang Yan, Lu Hai, Dazin Paul, Kapila Yvonne
Abstract excerpt
Resistance to anoikis, or apoptosis triggered by detachment from the extracellular matrix (ECM), lengthens the survival of malignant cells, facilitating reattachment and colonization of secondary sites. To examine the molecular mechanisms underlying resistance to anoikis in human oral squamous cell carcinoma (SCC) cells, we cultured human squamous carcinoma (HSC-3) cells in suspension on plates coated with...
Topics
- Animals
- Anoikis
- Antineoplastic Agents
- Carcinoma, Squamous Cell
- Cell Aggregation
- Cell Culture Techniques
- Cell Line, Tumor
- Cell Survival
- Extracellular Matrix
- Fibronectins