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Article

Chemoresistance of cancer floating cells is independent of their ability to form 3D structures: Implications for anticancer drug screening.

Journal of cellular physiology - 1 Apr 2019

Kaushik Vivek, Yakisich Juan S, Way Lillian Frances, Azad Neelam, Iyer Anand K V

Abstract excerpt

Three-dimensional (3D) culture systems such as floating spheroids (FSs) and floating tumorspheres (FTs) are widely used as tumor models of chemoresistance. FTs are considered to be enriched in cancer stem-like cells (CS-LCs). In this study, we used cancer cell lines (lung H460, prostate LnCAP, and breast MCF-7) able to form FSs under anchorage-independent conditions and compared with cell lines (prostate PC3 and...

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Identifiers

PMID: 30191978
DOI: 10.1002/jcp.27239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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