Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrins regulate the apoptotic response to DNA damage through modulation of p53.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Lewis Jean McArthur, Truong Tony Nguyen, Schwartz Martin Alexander

Abstract excerpt

p53 mediates apoptosis of cells after DNA damage including tumor cells after radiation or chemotherapy. Survival of isolated cancer cells after therapy leads to recurrence of therapy-resistant tumors. We now show that for some melanoma, sarcoma, or fibroblastic cell types that survive without integrin-mediated adhesion, apoptosis in response to DNA damage requires cell adhesion. This effect correlates with rapid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 3
Share to Caspases
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrins

Share to Proto-Oncogene Proteins c-mdm2

Share to Radiation, Ionizing

Share to Sarcoma

Share to Tumor Suppressor Protein p14ARF

Source

Open in PubMed Open full text

Identifiers

PMID: 11904424
DOI: 10.1073/pnas.062698499
PMCID: PMC122574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrins regulate the apoptotic response to DNA damage through modulation of p53.PMID 11904424Read ↗

Integrin signaling: specificity and control of cell survival and cell cycle progressionSemantic proximity Read ↗

Involvement of integrins in cell survivalSemantic proximity Read ↗

Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and DifferentiationSemantic proximity Read ↗

Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.Semantic proximity Read ↗

In an adhesion dependent human gastric adenocarcinoma cell line, integrin ligation without adhesion rescues from anoikis but is not sufficient for cell cycle progression.Semantic proximity Read ↗

H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts.Semantic proximity Read ↗

Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.Semantic proximity Read ↗

Reduction in drug-induced DNA double-strand breaks associated with β1 integrin–mediated adhesion correlates with drug resistance in U937 cellsSemantic proximity Read ↗

Mechanical stretch-induced apoptosis in smooth muscle cells is mediated by beta1-integrin signaling pathways.Semantic proximity Read ↗

αII-Spectrin Is Critical for Cell Adhesion and Cell CycleSemantic proximity Read ↗

Cell Adhesion to Fibronectin (CAM-DR) Influences Acquired Mitoxantrone Resistance in U937 CellsSemantic proximity Read ↗

Growth inhibition by anchorage-deficiency is associated with increased level but reduced phosphorylation of mutant p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.