Article
In an adhesion dependent human gastric adenocarcinoma cell line, integrin ligation without adhesion rescues from anoikis but is not sufficient for cell cycle progression.
Cell death and differentiation - 1 Jul 2001
Caruso D A, McIntyre B W
Abstract excerpt
STAD cells are the adherent parental apoptotic line from which two sublines were cloned that differed in their response to suspended culturing conditions, one clone STAD.APO is apoptotic and the other STAD.ARR goes into cell cycle arrest. Using this system we have found that the addition of soluble collagen can rescue STAD and STAD.APO cells from anoikis, and it can also affect STAD.ARR cells by overcoming the...
Topics
- Actins
- Adenocarcinoma
- Anoikis
- Antibodies, Monoclonal
- Cell Adhesion
- Cell Cycle
- Cell Division
- Cell Size
- Collagen
- Extracellular Matrix
- Focal Adhesion Kinase 1