Article
Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma.
Oral oncology - 1 May 2007
Kupferman Michael E, Patel Vyomesh, Sriuranpong Virote, Amornphimoltham Panamwat, Jasser Samar A, Mandal Mahitosh, Zhou Ge, Wang Jing, Coombes Kevin, Multani Asha, Pathak Sen, Silvio Gutkind J, Myers Jeffrey N
Abstract excerpt
Oral cavity squamous cell carcinoma (OSCC) is one of the leading causes of cancer deaths worldwide and most of these deaths result from local-regional recurrence and metastases. Evasion of apoptosis is an important hallmark of cancer development and progression, and previous studies have shown that evasion of anoikis, or detachment-induced apoptosis, correlates with a more aggressive phenotype of carcinoma cells...
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