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Article

Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity.

Diabetologia - 1 Jun 1997

Roche C, Boutin P, Dina C, Gyapay G, Basdevant A, Hager J, Guy-Grand B, Clément K, Froguel P

Abstract excerpt

Synthesis and release of neuropeptide Y (NPY) are both regulated by leptin binding to its hypothalamic receptor mediating some of the effects of leptin on food intake. Moreover, NPY administration is a powerful stimulant of feeding behaviour. Thus, we investigated the potential implication of NPY, NPY-Y1 and -Y5 subtype receptors [rNPY-Y1/-Y5] in the development of human obesity. Two complementary genetic...

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Source

Identifiers

PMID: 9222646
DOI: 10.1007/s001250050732

Genes

NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity.PMID 9222646Read ↗

Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.Semantic proximity Read ↗

Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects.Semantic proximity Read ↗

Variants in the 5' region of the neuropeptide Y receptor Y2 gene (NPY2R) are associated with obesity in 5,971 white subjects.Semantic proximity Read ↗

Screening for mutations in the neuropeptide Y Y5 receptor gene in cohorts belonging to different weight extremes.Semantic proximity Read ↗

Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians.Semantic proximity Read ↗

Sequence variation within the neuropeptide Y gene and obesity in Mexican Americans.Semantic proximity Read ↗

Neuropeptide Y gene polymorphisms are not associated with obesity in a South Indian population.Semantic proximity Read ↗

Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.Semantic proximity Read ↗

Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men.Semantic proximity Read ↗

Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men.Semantic proximity Read ↗

Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.Semantic proximity Read ↗

Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.Semantic proximity Read ↗

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