Article
Angiopoietin-1 causes reversible degradation of the portal microcirculation in mice: implications for treatment of liver disease.
The American journal of pathology - 1 Sept 2004
Ward Nicole L, Haninec Alexandra L, Van Slyke Paul, Sled John G, Sturk Celina, Henkelman R Mark, Wanless Ian R, Dumont Daniel J
Abstract excerpt
In many different liver diseases, such as cirrhosis, degradation of the microcirculation, including obliteration of small portal or hepatic veins contributes to disease-associated portal hypertension. The present study demonstrates the importance of angiogenesis in the establishment of arteriovenous shunts and the accompanying changes to the venous bed. One aspect of angiogenesis involves the branching of new...
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