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Article

The role of CLOCK gene in psychiatric disorders: Evidence from human and animal research.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2018

Schuch Jaqueline B, Genro Julia P, Bastos Clarissa R, Ghisleni Gabriele, Tovo-Rodrigues Luciana

Abstract excerpt

The circadian clock system drives daily rhythms in physiology, metabolism, and behavior in mammals. Molecular mechanisms of this system consist of multiple clock genes, with Circadian Locomotor Output Cycles Kaput (CLOCK) as a core member that plays an important role in a wide range of behaviors. Alterations in the CLOCK gene are associated with common psychiatric disorders as well as with circadian disturbances...

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PMID: 28902457
DOI: 10.1002/ajmg.b.32599

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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