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Article

Innate immunity in early chordates and the appearance of adaptive immunity

25 May 2004

Abstract excerpt

In the urochordate Ciona intestinalis some membrane Immunoglobulin superfamily members with ancestral features of antigen receptors are homologs of vertebrate adhesion molecules acting as virus receptors. They include the following: the junction adhesion molecule (reovirus receptor) (JAM), the Cortical thymocyte marker of Xenopus (CTX family) (Coxsackie's virus receptor) and the poliovirus receptor (PVR). In...

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PMID: 15330258
DOI: 10.1016/j.crvi.2004.04.004

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