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Article

Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families

4 Feb 2010

Abstract excerpt

BACKGROUND: Most rapidly evolving gene families are involved in immune responses and reproduction, two biological functions which have been assigned to the carcinoembryonic antigen (CEA) gene family. To gain insights into evolutionary forces shaping the CEA gene family we have analysed this gene family in 27 mammalian species including monotreme and marsupial lineages. RESULTS: Phylogenetic analysis provided...

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PMID: 20132533
DOI: 10.1186/1741-7007-8-12

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