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Article

The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domains.

BMC evolutionary biology - 19 Jun 2008

Desai Salil, Heffelfinger Amy K, Orcutt Timothy M, Litman Gary W, Yoder Jeffrey A

Abstract excerpt

BACKGROUND: Novel immune-type receptor (NITR) genes are members of diversified multigene families that are found in bony fish and encode type I transmembrane proteins containing one or two extracellular immunoglobulin (Ig) domains. The majority of NITRs can be classified as inhibitory receptors that possess cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs). A much smaller number of NITRs can be...

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Identifiers

PMID: 18565225
DOI: 10.1186/1471-2148-8-177
PMCID: PMC2442602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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