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Article

Ancient phylogenetic beginnings of immunoglobulin hypermutation.

Journal of molecular evolution - 1 Nov 2006

Kubrycht Jaroslav, Sigler Karel, Růzicka Michal, Soucek Pavel, Borecký Jirí, Jezek Petr

Abstract excerpt

Many structures and molecules closely related to those involved in the specific process of immunoglobulin (Ig) hypermutation existed before the appearance of primordial Ig genes. Consequently, these structures can be found even in animals and organisms distinct from vertebrates; likewise, homologues of hypermutation enzymes are present in a broad range of species, from bacteria to mammals. Our analysis, based...

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Identifiers

PMID: 17031458
DOI: 10.1007/s00239-006-0051-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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