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Article

Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.

The EMBO journal - 8 Feb 2006

Kharkovets Tatjana, Dedek Karin, Maier Hannes, Schweizer Michaela, Khimich Darina, Nouvian Régis, Vardanyan Vitya, Leuwer Rudolf, Moser Tobias, Jentsch Thomas J

Abstract excerpt

KCNQ4 is an M-type K+ channel expressed in sensory hair cells of the inner ear and in the central auditory pathway. KCNQ4 mutations underlie human DFNA2 dominant progressive hearing loss. We now generated mice in which the KCNQ4 gene was disrupted or carried a dominant negative DFNA2 mutation. Although KCNQ4 is strongly expressed in vestibular hair cells, vestibular function appeared normal. Auditory function was...

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Identifiers

PMID: 16437162
DOI: 10.1038/sj.emboj.7600951
PMCID: PMC1383535

Genes

KCNQ4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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