Article
Modeling hair cell tuning by expression gradients of potassium channel beta subunits.
Biophysical journal - 1 Jan 2002
Ramanathan Krishnan, Fuchs Paul A
Abstract excerpt
The receptor potential of sensory hair cells arises from the gating of mechanosensitive cation channels, but its amplitude and time course also depend on the number and kinetics of voltage-gated ion channels in each cell. Prominent among these are "BK" potassium channels encoded by the slo gene that support electrical tuning in some hair cells. Hair cells tuned to low frequencies have slowly gating BK channels,...
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