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Article

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.

Cell - 5 Feb 1999

Kubisch C, Schroeder B C, Friedrich T, Lütjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch T J

Abstract excerpt

Potassium channels regulate electrical signaling and the ionic composition of biological fluids. Mutations in the three known genes of the KCNQ branch of the K+ channel gene family underlie inherited cardiac arrhythmias (in some cases associated with deafness) and neonatal epilepsy. We have now c...

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Topics

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Share to Ear, Inner
Share to Hair Cells, Auditory, Outer
Share to Hearing Loss, Sensorineural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KCNQ Potassium Channels

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Share to Potassium Channels, Voltage-Gated

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Source

Identifiers

PMID: 10025409
DOI: 10.1016/s0092-8674(00)80556-5

Genes

KCNQ4
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10025409-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.PMID 10025409Read ↗

Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.Semantic proximity Read ↗

KCNQ4 mutations associated with nonsyndromic progressive sensorineural hearing loss.Semantic proximity Read ↗

A novel KCNQ4 gene variant (c.857A>G; p.Tyr286Cys) in an extended family with non‑syndromic deafness 2A.Semantic proximity Read ↗

Mutations in the KCNQ4 K+ channel gene, responsible for autosomal dominant hearing loss, cluster in the channel pore region.Semantic proximity Read ↗

KCNQ potassium channels: physiology, pathophysiology, and pharmacology.Semantic proximity Read ↗

A novel pore-region mutation, c.887G > A (p.G296D) in KCNQ4, causing hearing loss in a Chinese family with autosomal dominant non-syndromic deafness 2.Semantic proximity Read ↗

Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss.Semantic proximity Read ↗

Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.Semantic proximity Read ↗

Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.Semantic proximity Read ↗

Neuronal KCNQ potassium channels: physiology and role in disease.Semantic proximity Read ↗

Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development.Semantic proximity Read ↗

A humanized murine model, demonstrating dominant progressive hearing loss caused by a novel KCNQ4 mutation (p.G228D) from a large Chinese family.Semantic proximity Read ↗

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