Article
The melaminophenyl arsenicals melarsoprol and melarsen oxide interfere with thiamine metabolism in the fission yeast Schizosaccharomyces pombe.
Antimicrobial agents and chemotherapy - 1 Sept 2004
Schweingruber M Ernst
Abstract excerpt
The melaminophenyl arsenical melarsoprol is the main drug used against late-stage sleeping sickness caused by Trypanosoma brucei subspecies. Its active metabolite in the human body is melarsen oxide. Here, it is shown that this metabolite inhibits growth of the fission yeast Schizosaccharomyces pombe and that its toxicity can be abolished efficiently by thiamine (vitamin B(1)), thiamine analogues, and the...
Topics
- Arsenicals
- Culture Media
- Melarsoprol
- Mutation
- Oxides
- Pyrimidines
- Schizosaccharomyces
- Thiamine
- Trypanocidal Agents