Article
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
Molecular microbiology - 1 May 2015
Munday Jane C, Tagoe Daniel N A, Eze Anthonius A, Krezdorn Jessica A M, Rojas López Karla E, Alkhaldi Abdulsalam A M, McDonald Fiona, Still Jennifer, Alzahrani Khalid J, Settimo Luca, De Koning Harry P
Abstract excerpt
The Trypanosoma brucei aminopurine transporter P2/TbAT1 has long been implicated in the transport of, and resistance to, the diamidine and melaminophenyl arsenical classes of drugs that form the backbone of the pharmacopoeia against African trypanosomiasis. Genetic alterations including deletions and single nucleotide polymorphisms (SNPs) have been observed in numerous strains and clinical isolates. Here, we...
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