Article
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.
Eukaryotic cell - 1 Oct 2003
Matovu Enock, Stewart Mhairi L, Geiser Federico, Brun Reto, Mäser Pascal, Wallace Lynsey J M, Burchmore Richard J, Enyaru John C K, Barrett Michael P, Kaminsky Ronald, Seebeck Thomas, de Koning Harry P
Abstract excerpt
Sleeping sickness, caused by Trypanosoma brucei spp., has become resurgent in sub-Saharan Africa. Moreover, there is an alarming increase in treatment failures with melarsoprol, the principal agent used against late-stage sleeping sickness. In T. brucei, the uptake of melarsoprol as well as diamidines is thought to be mediated by the P2 aminopurine transporter, and loss of P2 function has been implicated in...
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