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Article

Modeling the site-specific variation of selection patterns along lineages.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004

Guindon Stéphane, Rodrigo Allen G, Dyer Kelly A, Huelsenbeck John P

Abstract excerpt

The unambiguous footprint of positive Darwinian selection in protein-coding DNA sequences is revealed by an excess of nonsynonymous substitutions over synonymous substitutions compared with the neutral expectation. Methods for analyzing the patterns of nonsynonymous and synonymous substitutions usually rely on stochastic models in which the selection regime may vary across the sequence but remains constant across...

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Share to Amino Acid Substitution
Share to Data Interpretation, Statistical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, env

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Share to Sequence Analysis, Protein

Share to Sequence Analysis, RNA

Source

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Identifiers

PMID: 15326304
DOI: 10.1073/pnas.0402177101
PMCID: PMC516501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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