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Article

Modeling HIV-1 drug resistance as episodic directional selection.

PLoS computational biology - 1 Jan 2012

Murrell Ben, de Oliveira Tulio, Seebregts Chris, Kosakovsky Pond Sergei L, Scheffler Konrad

Abstract excerpt

The evolution of substitutions conferring drug resistance to HIV-1 is both episodic, occurring when patients are on antiretroviral therapy, and strongly directional, with site-specific resistant residues increasing in frequency over time. While methods exist to detect episodic diversifying selection and continuous directional selection, no evolutionary model combining these two properties has been proposed. We...

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Identifiers

PMID: 22589711
DOI: 10.1371/journal.pcbi.1002507
PMCID: PMC3349733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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