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Article

Pax6 interacts with cVax and Tbx5 to establish the dorsoventral boundary of the developing eye.

The Journal of biological chemistry - 5 Nov 2004

Leconte Laurence, Lecoin Laure, Martin Patrick, Saule Simon

Abstract excerpt

Dorsoventral pattern formation of the optic cup is essential for vertebrate eye morphogenesis and retinotectal topographic mapping. Dorsal and ventral aspects of the eye are distinct at early stages of development; cVax homeodomain protein expression is confined to the ventral optic cup, whereas Tbx5 (T-box transcription factor) expression domain becomes restricted to the dorsal region. Misexpression of cVax or...

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Source

Identifiers

PMID: 15322073
DOI: 10.1074/jbc.M406624200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pax6 interacts with cVax and Tbx5 to establish the dorsoventral boundary of the developing eye.PMID 15322073Read ↗

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