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Article

Loss of Tbx2 delays optic vesicle invagination leading to small optic cups.

Developmental biology - 15 Sept 2009

Behesti Hourinaz, Papaioannou Virginia E, Sowden Jane C

Abstract excerpt

Tbx2 is a T-box transcription factor gene that is dynamically expressed in the presumptive retina during optic vesicle invagination. Several findings implicate Tbx2 in cell cycle regulation, including its overexpression in tumours and regulation of proliferation during heart development. We investigated the role of Tbx2 in optic cup formation by analysing mice with a targeted homozygous mutation in Tbx2. Loss of...

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Identifiers

PMID: 19576202
DOI: 10.1016/j.ydbio.2009.06.026
PMCID: PMC2735611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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