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Article

Competitive growth advantage of nontoxigenic mutants in the stationary phase in archival cultures of pathogenic Vibrio cholerae strains.

Infection and immunity - 1 Sept 2004

Paul Kalidas, Ghosh Amalendu, Sengupta Nilanjan, Chowdhury Rukhsana

Abstract excerpt

Spontaneous nontoxigenic mutants of highly pathogenic Vibrio cholerae O1 strains accumulate in large numbers during long-term storage of the cultures in agar stabs. In these mutants, production of the transcriptional regulator ToxR was reduced due to the presence of a mutation in the ribosome-binding site immediately upstream of the toxR open reading frame. Consequently, the ToxR-dependent virulence regulon was...

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Identifiers

PMID: 15322049
DOI: 10.1128/IAI.72.9.5478-5482.2004
PMCID: PMC517435

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