Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae

19 Nov 2012

Abstract excerpt

BACKGROUND: Nontypeable Haemophilus influenzae (NTHi) is a significant human pathogen responsible for respiratory tract infections and the most common cause of recurrent otitis media. Type II toxin-antitoxin (TA) systems are genetic elements that code for a stable protein toxin and a labile antitoxin that are thought to be involved in metabolic regulation of bacteria by enabling a switch to a dormant state under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections and Vaccines
Share to Microbial infections and disease research
Share to Pneumonia and Respiratory Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23157645
DOI: 10.1186/1471-2180-12-263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzaePMID 23157645Read ↗

VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease.Semantic proximity Read ↗

Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site.Semantic proximity Read ↗

Structural Determinants for Antitoxin Identity and Insulation of Cross Talk between Homologous Toxin-Antitoxin Systems.Semantic proximity Read ↗

Homologous VapC Toxins Inhibit Translation and Cell Growth by Sequence-Specific Cleavage of tRNA fMetSemantic proximity Read ↗

Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus.Semantic proximity Read ↗

Targeting Type II Toxin–Antitoxin Systems as Antibacterial StrategiesSemantic proximity Read ↗

PATHOGENESIS OF NON-TYPEABLE HAEMOPHILUS INFLUENZAE INFECTIONS IN CHRONIC SUPPURATIVE LUNG DISEASESemantic proximity Read ↗

Indirect Pathogenicity of <i>Haemophilus influenzae</i> and <i>Moraxella catarrhalis</i> in Polymicrobial Otitis Media Occurs via Interspecies Quorum SignalingSemantic proximity Read ↗

Regulation of enteric vapBC transcription: induction by VapC toxin dimer-breaking.Semantic proximity Read ↗

Haemophilus influenzaeSemantic proximity Read ↗

Molecular determinants of the pathogenesis of disease due to non-typable<i>Haemophilus influenzae</i>Semantic proximity Read ↗

Functional RelBE-Family Toxin-Antitoxin Pairs Affect Biofilm Maturation and Intestine Colonization in Vibrio cholerae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.