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Article

A fadD mutant of Vibrio cholerae is impaired in the production of virulence factors and membrane localization of the virulence regulatory protein TcpP.

Infection and immunity - 1 Jan 2011

Ray Sreejana, Chatterjee Epshita, Chatterjee Arpita, Paul Kalidas, Chowdhury Rukhsana

Abstract excerpt

In the enteric pathogen Vibrio cholerae, expression of the major virulence factors is controlled by the hierarchical expression of several regulatory proteins comprising the ToxR regulon. In this study, we demonstrate that disruption of the fadD gene encoding a long-chain fatty acyl coenzyme A ligase has marked effects on expression of the ToxR virulence regulon, motility, and in vivo lethality of V. cholerae. In...

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Identifiers

PMID: 21041490
DOI: 10.1128/IAI.00663-10
PMCID: PMC3019873

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