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Comparative genomics reveals a functional thyroid-specific element in the far upstream region of the PAX8 gene

14 May 2010

Abstract excerpt

BACKGROUND: The molecular mechanisms leading to a fully differentiated thyrocite are still object of intense study even if it is well known that thyroglobulin, thyroperoxidase, NIS and TSHr are the marker genes of thyroid differentiation. It is also well known that Pax8, TTF-1, Foxe1 and Hhex are the thyroid-enriched transcription factors responsible for the expression of the above genes, thus are responsible for...

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PMID: 20470391
DOI: 10.1186/1471-2164-11-306

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