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Article

hCDC4 gene mutations in endometrial cancer.

Cancer research - 15 Aug 2002

Spruck Charles H, Strohmaier Heimo, Sangfelt Olle, Müller Hannes M, Hubalek Michael, Müller-Holzner Elisabeth, Marth Christian, Widschwendter Martin, Reed Steven I

Abstract excerpt

Cyclin-dependent kinase 2 activated by cyclin E is involved in the initiation of DNA replication and other S phase functions. Consistent with this role, cyclin E protein accumulates at the G1-S phase transition and declines during early S phase. This profile of expression is the result of periodic transcription and ubiquitin-mediated proteolysis directed by SCF(hCdc4). However, in many types of human tumors...

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PMID: 12183400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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