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Article

APOBEC3G versus reverse transcriptase in the generation of HIV-1 drug-resistance mutations

31 Aug 2004

Abstract excerpt

HIV-1 is known for its high adaptive capacity, which is most seriously demonstrated by its ability to escape from potent antiviral drugs in treated HIV-infected individuals. Viral escape occurs by the selection of drug-resistant variants with single or multiple amino acid substitutions in the targeted enzymes reverse transcriptase (RT) or protease (PR), and more recently the evelope protein (Env). HIV-1 genetic...

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PMID: 15316354
DOI: 10.1097/00002030-200409030-00022

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