Article
Natural polymorphisms associated with resistance to new antivirals against HCV in newly diagnosed HIV-HCV-coinfected patients.
Antiviral therapy - 1 Jan 2011
Treviño Ana, de Mendoza Carmen, Parra Patricia, Rodríguez Carmen, Madejón Antonio, Plaza Zulema, del Romero Jorge, Poveda Eva, Soriano Vincent
Abstract excerpt
BACKGROUND: Direct acting antivirals (DAA) targeting the HCV serine protease and RNA polymerase have recently entered clinical development. Information about primary resistance to these compounds in HIV-HCV-coinfected patients is scarce. METHODS: All individuals newly diagnosed with HIV-1 at several clinics in Madrid between 2000 and 2010 were tested for serum HCV antibody and HCV RNA. The NS3 protease and NS5B...
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