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Article

Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice.

The EMBO journal - 1 Jan 1992

Pereira P, Zijlstra M, McMaster J, Loring J M, Jaenisch R, Tonegawa S

Abstract excerpt

The gamma delta T cell receptor (TCR) of the hybridoma KN6 recognizes the self molecule encoded by a class I gene which maps within the TL region of the major histocompatibility complex (MHC) of H-2b mice. Mice transgenic (Tg) for this TCR were crossed with mice genetically deficient in beta 2-microglobulin (beta 2m). No mature Tg gamma delta T cells were detected in the thymus or the spleen of the beta 2m- gamma...

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Identifiers

PMID: 1531458
DOI: 10.1002/j.1460-2075.1992.tb05023.x
PMCID: PMC556421

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Source receipt: pubmed, retrieved 7 Sept 2026.

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