Article
LIM-homeodomain genes in mammalian development and human disease.
Molecular biology reports - 1 Jun 2005
Hunter Chad S, Rhodes Simon J
Abstract excerpt
The human and mouse genomes each contain at least 12 genes encoding LIM homeodomain (LIM-HD) transcription factors. These gene regulatory proteins feature two LIM domains in their amino termini and a characteristic DNA binding homeodomain. Studies of mouse models and human patients have established that the LIM-HD factors are critical for the development of specialized cells in multiple tissue types, including...
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