Article
A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.
The Journal of experimental medicine - 4 Sept 2006
Friend Lindzy D, Shah Dulari D, Deppong Christine, Lin Joseph, Bricker Traci L, Juehne Twyla I, Rose Christine M, Green Jonathan M
Abstract excerpt
Activation of naive T cells requires the integration of signals through the antigen receptor and CD28. Although there is agreement on the importance of CD28, there remains controversy on the mechanism by which CD28 regulates T cell function. We have generated a gene-targeted knockin mouse expressing a mutation in the C-terminal proline-rich region of the cytoplasmic tail of CD28. Our analysis conclusively showed...
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