Article
[The use of gene chip in detecting Mycobacterium tuberculosis resistant to rifampin and isoniazid].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases - 1 Jul 2004
Cui Zhen-ling, Jing Feng-xiang, Hu Zhong-yi, Wu Zi-rong, Zhao Jian-long
Abstract excerpt
OBJECTIVE: To study the application of gene chip in detecting Mycobacterium tuberculosis resistant to rifampin (RFP) and isoniazid (INH). METHODS: Probes were designed and the gene chip was fabricated according to the 30 single nucleotide polymorphisms of 11 mutations on 4 genes associated with RFP and INH resistance. The mutations in Mycobacterium tuberculosis were detected by gene chip to analyze the resistance...
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