Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study.

Scientific reports - 9 Sept 2021

Feng Gang, Han Wenhao, Shi Jinyan, Xia Rongrong, Xu Jianchun

Abstract excerpt

Most Mycobacterium tuberculosis (Mtb) resistant to rifampicin (RIF) has mutations in the rpoB gene, while most Mtb resistant to isoniazid (INH) has mutations in the katG gene or inhA promoter. We used gene chip technology to detect mutations in these genes to determine the resistance of Mtb to RIF and INH. A total of 4148 clinical specimens with sputum smear positivity for acid-fast bacilli (AFB) were detected....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antitubercular
Share to Catalase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Isoniazid

Share to Oxidoreductases

Share to Rifampin

Share to Sputum

Share to Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 34504243
DOI: 10.1038/s41598-021-97559-y
PMCID: PMC8429459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Analysis of the application of a gene chip method for detecting Mycobacterium tuberculosis drug resistance in clinical specimens: a retrospective study.PMID 34504243Read ↗

The Analysis of Drug-Resistant Gene Mutations of Mycobacterium tuberculosis by GeneChip in Lianyungang, China.Semantic proximity Read ↗

[The use of gene chip in detecting Mycobacterium tuberculosis resistant to rifampin and isoniazid].Semantic proximity Read ↗

Multicenter Evaluation of Genechip for Detection of Multidrug-Resistant Mycobacterium tuberculosisSemantic proximity Read ↗

Tag Array gene chip rapid diagnosis anti-tuberculosis drug resistance in pulmonary tuberculosis -a feasibility study.Semantic proximity Read ↗

GeneChip analysis of resistant Mycobacterium tuberculosis with previously treated tuberculosis in Changchun.Semantic proximity Read ↗

[Rapid detection of Mycobacterium tuberculosis resistance to rifampin using DNA chip].Semantic proximity Read ↗

Comparison of a conventional antimicrobial susceptibility assay to an oligonucleotide chip system for detection of drug resistance in Mycobacterium tuberculosis isolates.Semantic proximity Read ↗

Evaluation of the CombiChip Mycobacteria Drug-Resistance detection DNA chip for identifying mutations associated with resistance to isoniazid and rifampin in Mycobacterium tuberculosis.Semantic proximity Read ↗

A novel genotypic test for rapid detection of multidrug-resistant Mycobacterium tuberculosis isolates by a multiplex probe array.Semantic proximity Read ↗

[Rapid detection of rpoB mutations in Mycobacterium tuberculosis by gene array].Semantic proximity Read ↗

[Establishment of a method with micro-channel electrophoresis for detecting the mutations of isoniazid-resistant genes in Mycobacterium tuberculosis].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.